Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker.

ABSTRACT: Evidence points epicardial adipose tissue (EAT) as an emerging cardiovascular risk marker. Whether genetic polymorphisms linked with atherosclerosis are associated with higher EAT is still unknown. We aim to assess the role of genetic burden of atherosclerosis and its association to EAT in a cohort of asymptomatic individuals without coronary disease. A total of 996 participants were prospectively enrolled in a single Portuguese center. EAT volume was measured by Cardiac Computed Tomography and participants were distributed into 2 groups, above and below median EAT. SNPs were genotyped and linked to their respective pathophysiological axes. A multiplicative genetic risk score (mGRS) was constructed, representing the genetic burden of the studied SNPs. To evaluate the association between ge

SUBMITTER: Sousa JA 

PROVIDER: S-EPMC8255575 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature