Cdan1 Is Essential for Primitive Erythropoiesis.

ABSTRACT: Congenital dyserythropoietic anemia type I (CDA I) is an autosomal recessive disease characterized by moderate to severe macrocytic anemia and pathognomonic morphologic abnormalities of the erythroid precursors, including spongy heterochromatin. The disease is mainly caused by mutations in CDAN1 (encoding for Codanin-1). No patients with homozygous null type mutations have been described, and mouse null mutants die during early embryogenesis prior to the initiation of erythropoiesis. The cellular functions of Codanin-1 and the erythroid specificity of the phenotype remain elusive. To investigate the role of Codanin-1 in erythropoiesis, we crossed mice carrying the Cdan1 floxed allele (Cdan ^fl/fl ) with mice expressing Cre-recombinase under regulation of the

SUBMITTER: Noy-Lotan S 

PROVIDER: S-EPMC8255688 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature