The Heteromeric Complex Formed by Dopamine Receptor D₅ and CCR9 Leads the Gut Homing of CD4⁺ T Cells Upon Inflammation.

ABSTRACT:

Background and aims

CD4⁺ T cells constitute central players in inflammatory bowel diseases (IBDs), driving inflammation in the gut mucosa. Current evidence indicates that CCR9 and the integrin α4β7 are necessary and sufficient to imprint colonic homing on CD4⁺ T cells upon inflammation. Interestingly, dopaminergic signaling has been previously involved in leukocyte homing. Despite dopamine levels are strongly reduced in the inflamed gut mucosa, the role of dopamine in the gut homing of T cells remains unknown. Here, we study how dopaminergic signaling affects T cells upon gut inflammation.

Methods

Gut inflammation was induced by transfer of naïve T cells into Rag1^-/- mice or by administration of dextran sodium sulfate. T cell migration and di

SUBMITTER: Osorio-Barrios F 

PROVIDER: S-EPMC8255938 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature