Conditions Mimicking the Cancer Microenvironment Modulate the Functional Outcome of Human Chorionic Villus Mesenchymal Stem/Stromal Cells in vitro.

ABSTRACT: Mesenchymal stem/stromal cells isolated from chorionic villi of human term placentae (CV-MSCs) possess unique biological characters. They exhibit self-renewal, directional migration, differentiation, and immunomodulatory effects on other cell lineages, by virtue of which they can be utilized as therapeutic carriers, for drug targeting, and therapy. Tumors display characteristic features of a damaged tissue microenvironment, which is saturated with conditions such as hypoxia, sustained inflammation, and increased oxidative stress. CV-MSCs function normally in a high oxidative stress environment induced by hydrogen peroxide (H₂O₂) and glucose and also protect endothelial cells from their damaging effects. For their therapeutic applications in a disease like cancer, it i

SUBMITTER: Basmaeil Y 

PROVIDER: S-EPMC8255990 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature