PRG2 and AQPEP are misexpressed in fetal membranes in placenta previa and percreta†.

ABSTRACT: The obstetrical conditions placenta accreta spectrum (PAS) and placenta previa are a significant source of pregnancy-associated morbidity and mortality, yet the specific molecular and cellular underpinnings of these conditions are not known. In this study, we identified misregulated gene expression patterns in tissues from placenta previa and percreta (the most extreme form of PAS) compared with control cases. By comparing this gene set with existing placental single-cell and bulk RNA-Seq datasets, we show that the upregulated genes predominantly mark extravillous trophoblasts. We performed immunofluorescence on several candidate molecules and found that PRG2 and AQPEP protein levels are upregulated in both the fetal membranes and the placental disk in both conditions. While this increased

SUBMITTER: Zhang ET 

PROVIDER: S-EPMC8256106 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature