Effects of Fibrin Clot Inhibitors and Statins on the Intravesical Bacille Calmette-Guerin Therapy for Bladder Cancer: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objective

To assess the effect of fibrin clot inhibitors (aspirin, clopidogrel, and warfarin) and statins on intravesical BCG therapy.

Method

A systematic literature search was carried out through PubMed, Embase, and the Cochrane Central Search Library in March 2020. Accumulative analyses of odds ratios (ORs), hazard ratio (HR), and corresponding 95% confidence intervals (CIs) were performed. All analyses were performed by using Review Manager software version 5.3 and Stata 15.1.

Results

Four cohort studies and nine case-control studies containing 3,451 patients were included. The pooled analysis indicated that statins (HR = 1.00; 95%CI, 0.82 to 1.22; p = 1.00) and fibrin clot inhibitors (HR = 1.01; 95%CI, 0.64 to 1.59; p = 0.98) did not affect the effic

SUBMITTER: Cai Z 

PROVIDER: S-EPMC8256157 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature