New Polyketides With Anti-Inflammatory Activity From the Fungus Aspergillus rugulosa.

ABSTRACT: Two new polyketide compounds, asperulosins A and B (1-2), and one new prenylated small molecule, asperulosin C (3), along with nine known compounds (4-12), were isolated and identified from a fungus Aspergillus rugulosa. Their structures were extensively elucidated via HRESIMS, 1D, and 2D NMR analysis. The absolute configurations of the new compounds were determined by the comparison of their electronic circular dichroism (ECD), calculated ECD spectra, and the detailed discussion with those in previous reports. Structurally, compounds 1 and 2 belonged to the polyketide family and were from different origins. Compound 2 was constructed by five continuous quaternary carbon atoms, which occur rarely in natural products. All

SUBMITTER: Xu Q 

PROVIDER: S-EPMC8256160 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature