Safety of SARS-CoV-2 vaccines: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Various modalities of vaccines against coronavirus disease 2019 (COVID-19), based on different platforms and immunization procedures, have been successively approved for marketing worldwide. A comprehensive review for clinical trials assessing the safety of COVID-19 vaccines is urgently needed to make an accurate judgment for mass vaccination.

Main text

A systematic review and meta-analysis was conducted to determine the safety of COVID-19 vaccine candidates in randomized controlled trials (RCTs). Data search was performed in PubMed, Embase, Cochrane library, Scopus, Web of Science, and MedRxiv. Included articles were limited to RCTs on COVID-19 vaccines. A total of 73,633 subjects from 14 articles were included to compare the risks of adverse events following imm

SUBMITTER: Chen M 

PROVIDER: S-EPMC8256217 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature