LncRNA Ctcflos orchestrates transcription and alternative splicing in thermogenic adipogenesis.

ABSTRACT: The recruitment of thermogenic brite adipocytes within white adipose tissue attenuates obesity and metabolic comorbidities, arousing interest in understanding the underlying regulatory mechanisms. The molecular network of brite adipogenesis, however, remains largely unresolved. In this light, long noncoding RNAs (lncRNAs) emerged as a versatile class of modulators that control many steps within the differentiation machinery. Leveraging the naturally varying propensities of different inbred mouse strains for white adipose tissue browning, we identify the nuclear lncRNA Ctcflos as a pivotal orchestrator of thermogenic gene expression during brite adipocyte differentiation. Mechanistically, Ctcflos acts as a pleiotropic regulator, being essential for the transcriptional recruitment of the ear

SUBMITTER: Bast-Habersbrunner A 

PROVIDER: S-EPMC8256291 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature