Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis.

ABSTRACT: Early identification and treatment significantly improve clinical outcomes of psychotic disorders. Recent studies identified protein components of the complement and coagulation systems as key pathways implicated in psychosis. These specific protein alterations are integral to the inflammatory response and can begin years before the onset of clinical symptoms of psychotic disorder. Critically, they have recently been shown to predict the transition from clinical high risk to first-episode psychosis, enabling stratification of individuals who are most likely to transition to psychotic disorder from those who are not. This reinforces the concept that the psychosis spectrum is likely a central nervous system manifestation of systemic changes and highlights the need to investigate plasma prote

SUBMITTER: Heurich M 

PROVIDER: S-EPMC8256396 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature