Derivation and validation of a lipid-covered prognostic model for mature T-cell lymphomas.

ABSTRACT:

Background

Mature T-cell lymphomas (MTCLs), a group of diseases with high aggressiveness and vulnerable prognosis, lack for the accurate prognostic stratification systems at present. Novel prognostic markers and models are urgently demanded. Aberrant lipid metabolism is closely related to the tumor progression but its prognostic significance in MTCLs remains unexplored. This study aims to investigate the relationship between dysregulated lipid metabolism and survival prognosis of MTCLs and establish a novel and well-performed prognostic scoring system for MTCL patients.

Methods

A total of 173 treatment-naive patients were enrolled in this study. Univariate and multivariate Cox regression analysis were performed to assess the prognostic significance of serum lipid profiles an

SUBMITTER: Lu T 

PROVIDER: S-EPMC8256497 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature