Comparison of coenzyme Q10 or fish oil for prevention of intermittent hypoxia-induced oxidative injury in neonatal rat lungs.

ABSTRACT:

Background

Neonatal intermittent hypoxia (IH) results in oxidative distress in preterm infants with immature antioxidant systems, contributing to lung injury. Coenzyme Q10 (CoQ10) and fish oil protect against oxidative injury. We tested the hypothesis that CoQ10 is more effective than fish oil for prevention of IH-induced lung injury in neonatal rats.

Methods

Newborn rats were exposed to two clinically relevant IH paradigms at birth (P0): (1) 50% O₂ with brief hypoxia (12% O₂); or (2) room air (RA) with brief hypoxia (12% O₂), until P14 during which they were supplemented with daily oral CoQ10, fish oil, or olive oil from P0 to P14. Pups were studied at P14 or placed in RA until P21 with no further treatment. Lungs were assessed for histopath

SUBMITTER: D'Agrosa C 

PROVIDER: S-EPMC8256540 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature