Could age increase the strength of inverse association between ultraviolet B exposure and colorectal cancer?

ABSTRACT:

Background

Vitamin D has been identified as a potential protective factor in the development of colorectal cancer (CRC). We expect to see a stronger association of ultraviolet B (UVB) exposure and CRC crude rates with increasing age since chronic vitamin D deficiency leads to sustained molecular changes that increase cancer risk. The DINOMIT (disjunction, initiation, natural selection, overgrowth, metastasis, involution, and transition) model postulates various stages of cancer development due to vitamin D deficiency and the associated latency period. The purpose of this study is to examine this age-dependent inverse relationship globally.

Methods

In this ecological study, a series of linear and polynomial regression tests were performed between country-specific UVB estimate

SUBMITTER: Purushothaman VL 

PROVIDER: S-EPMC8256562 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature