Research article expression of surfactant protein-A and D, and CD9 in lungs of 1 and 30 day old foals.

ABSTRACT:

Background

Respiratory diseases are a major cause of morbidity and mortality in the horses of all ages including foals. There is limited understanding of the expression of immune molecules such as tetraspanins and surfactant proteins (SP) and the regulation of the immune responses in the lungs of the foals. Therefore, the expression of CD9, SP-A and SP-D in foal lungs was examined.

Results

Lungs from one day old (n = 6) and 30 days old (n = 5) foals were examined for the expression of CD9, SP-A, and SP-D with immunohistology and Western blots. Western blot data showed significant increase in the amount of CD9 protein (p = 0.0397) but not of SP-A and SP-D at 30 days of age compared to one day. Immunohistology detected CD9 in the alveolar septa and vascular endothelium but not

SUBMITTER: Bocking T 

PROVIDER: S-EPMC8256609 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature