Evaluation of antioxidant network proteins as novel prognostic biomarkers for head and neck cancer patients.

ABSTRACT:

Objectives

Recurrence rates for head and neck squamous cell carcinoma (HNSCC) approach 50% at 5 years. Current staging fails to identify patients with a worse prognosis who might benefit from intensified treatment, which warrants improved prognostic biomarkers. The purpose of this retrospective case study is to identify potential prognostic biomarkers in patients with HNSCC including APE1 (DNA repair/redox gene regulator), NRF2 and PPARGC1A (redox gene regulators), SOD3 and DCN (antioxidant proteins).

Materials and methods

Differential protein expression between benign, carcinoma in situ (CIS), and invasive HNSCC tissue specimens from 77 patients was assessed using immunohistochemistry. Protein expression was analyzed with multivariate, pair-wise, and Kaplan-Meier survival a

SUBMITTER: Wicker CA 

PROVIDER: S-EPMC8256620 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature