Immune cell profiling and antibody responses in patients with COVID-19.

ABSTRACT:

Background

Although there are a growing number of studies on evaluating lymphocyte subset counts as prognostic factors for COVID-19 disease severity, the lymphocyte subsets' analyses of both IgM and IgG responders and non-responders during the periods after onset of symptoms, have not been conducted yet. So, this study aimed to evaluate immune cell profiling of COVID-19 patients with and without antibody responses.

Methods

In this cross-sectional study, the levels of peripheral lymphocyte subsets were measured using flow cytometry in 53 patients with positive SARS-CoV-2 RT-PCR, for whom antibody testing of COVID-19 was performed.

Results

The white blood cell, neutrophil, and lymphocyte counts consistently decreased in the IgM and IgG non-responder group, while the dif

SUBMITTER: Rezaei M 

PROVIDER: S-EPMC8256640 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature