A high-resolution in vivo atlas of the human brain's benzodiazepine binding site of GABA_A receptors.

ABSTRACT: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the human brain and plays a key role in several brain functions and neuropsychiatric disorders such as anxiety, epilepsy, and depression. For decades, several in vivo and ex vivo techniques have been used to highlight the mechanisms of the GABA system, however, no studies have currently combined the techniques to create a high-resolution multimodal view of the GABA system. Here, we present a quantitative high-resolution in vivo atlas of the human brain benzodiazepine receptor sites (BZR) located on postsynaptic ionotropic GABA_A receptors (GABA_ARs), generated on the basis of in vivo [¹¹C]flumazenil Positron Emission Tomography (PET) data. Next, based on ex vivo autoradiography data, we

SUBMITTER: Norgaard M 

PROVIDER: S-EPMC8256681 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature