Distinct pathways of solid-to-solid phase transitions induced by defects: the case of dl-me-thio-nine.

ABSTRACT: Understanding of solid-to-solid phase transition mechanisms in polymorphic systems is of critical importance for rigorous control over polymorph purity in the pharmaceutical industry to achieve the desired bioavailability and efficacy of drugs. Ubiquitous defects in crystals may play an important role in the pathways of phase transitions. However, such effects remain poorly understood. Here, the effects of crystal defects on the solid-to-solid phase transformations between dl-me-thio-nine polymorphs α and β are investigated by means of experimental and computational approaches. Thermal analyses of polycrystalline powders show two endothermic peaks in the α-to-β phase transition (and two exothermic peaks for the reverse transition), in contrast with one thermal event observed for single cry

SUBMITTER: Shi G 

PROVIDER: S-EPMC8256715 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature