BMP-2 delivery strategy modulates local bone regeneration and systemic immune responses to complex extremity trauma.

ABSTRACT: Bone nonunions arising from large bone defects and composite injuries remain compelling challenges for orthopedic surgeons. Biological changes associated with nonunions, such as systemic immune dysregulation, can contribute to an adverse healing environment. Bone morphogenetic protein 2 (BMP-2), an osteoinductive and potentially immunomodulatory growth factor, is a promising strategy; however, burst release from the clinical standard collagen sponge delivery vehicle can result in adverse side effects such as heterotopic ossification (HO) and irregular bone structure, especially when using supraphysiological BMP-2 doses for complex injuries at high risk for nonunion. To address this challenge, biomaterials that strongly bind BMP-2, such as heparin methacrylamide microparticles (HMPs), may b

SUBMITTER: Vantucci CE 

PROVIDER: S-EPMC8256799 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature