Oral Vaccination Approaches for Anti-SHIV Immunity.

ABSTRACT: We modified a Sabin Oral Poliovirus Vaccine (OPV) vector to permit secretion of the antigens of interest with the goal of improving anti-HIV Env humoral responses in a SHIV mucosal immunization composed of DNA and recombinant OPVs. We evaluated stimulation of systemic and mucosal cell-mediated and humoral immunity in Rhesus macaques by two regimens, both involving a prime with a SHIV_BG505 DNA construct producing non-infectious particles formulated in lipid nanoparticles, administered in the oral cavity, and two different viral vector boostings, administered in the oral cavity and intestinally. Group 1 was boosted with rMVA-SHIVBG505, expressing SIV Gag/Pol and HIV_BG505 Env. Group 2 was boosted with a SHIV_BG505-OPV vaccine including a non-secreting SI

SUBMITTER: Velarde de la Cruz E 

PROVIDER: S-EPMC8256843 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature