Association of Single Nucleotide Polymorphism rs2228570 with Lumbar Disc Degeneration: A Case-Control Study and Meta-Analysis.

ABSTRACT:

Objective

To examine the association between single nucleotide polymorphisms (SNPs) rs2228570, rs731236, rs7975232, and rs1544410 and lumbar disc degeneration (LDD) predisposition.

Methods

A search strategy was carried out, and the data were extracted after being chosen by the inclusion and exclusion criteria. Pooled odds ratios and 95% confidence intervals were calculated to assess the association between the aforementioned SNPs and LDD under allelic, dominant, recessive, heterozygous, and homozygous genetic models. In addition, a case-control study involving 46 LDD cases and 45 controls was also performed in the analysis to verify the result.

Results

A total of 17 studies were included in this meta-analysis. The pooled results did not show any association between vi

SUBMITTER: Zhang H 

PROVIDER: S-EPMC8257063 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature