Damage, Healing, and Remodeling in Optogenetic Skeletal Muscle Bioactuators.

ABSTRACT: A deeper understanding of biological materials and the design principles that govern them, combined with the enabling technology of 3D printing, has given rise to the idea of "building with biology." Using these materials and tools, bio-hybrid robots or bio-bots, which adaptively sense and respond to their environment, can be manufactured. Skeletal muscle bioactuators are developed to power these bio-bots, and an approach is presented to make them dynamically responsive to changing environmental loads and robustly resilient to induced damage. Specifically, since the predominant cause of skeletal muscle loss of function is mechanical damage, the underlying mechanisms of damage are investigated in vitro, and an in vivo inspired healing strategy is developed to counteract this damage. The pro

SUBMITTER: Raman R 

PROVIDER: S-EPMC8257561 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature