Number of siblings and survival from childhood leukaemia: a national register-based cohort study from Sweden.

ABSTRACT:

Background

Previous studies suggest worse leukaemia survival for children with siblings, but the evidence is sparse, inconsistent and does not consider clinical factors. We explored the associations between number of siblings in the household, birth order and survival from childhood acute lymphoid leukaemia (ALL) and acute myeloid leukaemia (AML).

Methods

In this nationwide register-based study we included all children aged 1-14, diagnosed with ALL and AML between 1991-mid-2015 in Sweden (n = 1692). Using Cox regression models, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) according to number of siblings and birth order, adjusting for known prognostic and sociodemographic factors.

Results

A tendency towards better ALL survival among children with

SUBMITTER: Mogensen H 

PROVIDER: S-EPMC8257570 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature