Genome-wide association study of stimulant dependence.

ABSTRACT: Stimulant dependence is heritable, but specific genetic factors underlying the trait have not been identified. A genome-wide association study for stimulant dependence was performed in a discovery cohort of African- (AA) and European-ancestry (EA) subjects ascertained for genetic studies of alcohol, opioid, and cocaine use disorders. The sample comprised individuals with DSM-IV stimulant dependence (393 EA cases, 5288 EA controls; 155 AA cases, 5603 AA controls). An independent cohort from the family-based Collaborative Study on the Genetics of Alcoholism (532 EA cases, 7635 EA controls; 53 AA cases, AA 3352 controls) was used for replication. One variant in SLC25A16 (rs2394476, p = 3.42 × 10^-10, odds ratio [OR] = 3.70) was GWS in AAs. Four other loci showed suggestive evidence,

SUBMITTER: Cox J 

PROVIDER: S-EPMC8257618 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature