Urinary oestrogen steroidome as an indicator of the risk of localised prostate cancer progression.

ABSTRACT:

Background

Prostate cancer (PCa) is the most common cancer in North American men. Beyond the established contribution of androgens to disease progression, growing evidence suggest that oestrogen-related pathways might also be of clinical importance. The aim of this study was to explore the association of urinary oestrogen levels with clinical outcomes.

Methods

Urine samples from the prospective multi-institutional PROCURE cohort were collected before RP for discovery (n = 259) and validation (n = 253). Urinary total oestrogens (unconjugated + conjugated), including oestrone and oestradiol, their bioactive and inactive catechol and methyl derivatives (n = 15), were measured using mass spectrometry (MS).

Results

The median follow-up time for the discovery and replicatio

SUBMITTER: Emond JP 

PROVIDER: S-EPMC8257651 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature