The evaluation of zebrafish cardiovascular and behavioral functions through microfluidics.

ABSTRACT: This study proposed a new experimental approach for the vascular and phenotype evaluation of the non-anesthetized zebrafish with representative imaging orientations for heart, pectoral fin beating, and vasculature views by means of the designed microfluidic device through inducing the optomotor response and hydrodynamic pressure control. In order to provide the visual cues for better positioning of zebrafish, computer-animated moving grids were generated by an in-house control interface which was powered by the larval optomotor response, in conjunction with the pressure suction control. The presented platform provided a comprehensive evaluation of internal circulation and the linked external behaviors of zebrafish in response to the cardiovascular parameter changes. The insights from these

SUBMITTER: Subendran S 

PROVIDER: S-EPMC8257654 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature