MiR-146a regulates regulatory T cells to suppress heart transplant rejection in mice.

ABSTRACT: Regulatory T cells (Tregs), which characteristically express forkhead box protein 3 (Foxp3), are essential for the induction of immune tolerance. Here, we investigated microRNA-146a (miR-146a), a miRNA that is widely expressed in Tregs and closely related to their homeostasis and function, with the aim of enhancing the function of Tregs by regulating miR-146a and then suppressing transplant rejection. The effect of the absence of miR-146a on Treg function in the presence or absence of rapamycin was detected in both a mouse heart transplantation model and cell co-cultures in vitro. The absence of miR-146a exerted a mild tissue-protective effect by transiently prolonging allograft survival and reducing the infiltration of CD4⁺ and CD8⁺ T cells into the allografts. Meanw

SUBMITTER: Lu J 

PROVIDER: S-EPMC8257678 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature