The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases.

ABSTRACT: Cells are in constant adaptation to environmental changes to insure their proper functioning. When exposed to stresses, cells activate specific pathways to elicit adaptive modifications. Those changes can be mediated by selective modulation of gene and protein expression as well as by post-translational modifications, such as phosphorylation and proteolytic processing. Protein cleavage, as a controlled and limited post-translational modification, is involved in diverse physiological processes such as the maintenance of protein homeostasis, activation of repair pathways, apoptosis and the regulation of proliferation. Here we assessed by quantitative proteomics the proteolytic landscape in two cell lines subjected to low cisplatin concentrations used as a mild non-lethal stress paradigm. Thi

SUBMITTER: Conde-Rubio MDC 

PROVIDER: S-EPMC8257705 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature