Body mass index and absolute lymphocyte count predict disease-free survival in Korean breast cancer patients.

ABSTRACT:

Background

Our study evaluated the association between body mass index (BMI) and absolute lymphocyte count (ALC) in breast cancer patients and healthy females. Additionally, we determined the prognostic value of these factors in breast cancer.

Methods

We retrospectively identified 1225 primary invasive breast cancer patients and 35,991 healthy females. Factors including BMI and complete blood count associated with disease-free survival (DFS) were assessed using a multi-variable Cox proportional hazard model.

Results

BMI and ALC were positively correlated in breast cancer patients and healthy females (both P < 0.001). In multi-variable analysis, overweight or obese participants had worse DFS (hazards ratio [HR], 1.98; 95% confidence interval [CI], 1.34-2.92; P = 0.001)

SUBMITTER: Ko SM 

PROVIDER: S-EPMC8257741 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature