Circulating MicroRNAs in Relation to Esophageal Adenocarcinoma Diagnosis and Survival.

ABSTRACT:

Background and aims

Tissue miRNA can discriminate between esophageal adenocarcinoma (EA) and normal epithelium. However, no studies have examined a comprehensive panel of circulating miRNAs in relation to EA diagnosis and survival.

Methods

We used all 62 EA cases from the US Multi-Center case-control study with available serum matched 1:1 to controls. Cases were followed for vital status. MiRNAs (n = 2064) were assessed using the HTG EdgeSeq miRNA Whole Transcriptome Assay. Differential expression analysis of miRNAs in relation to case-control status was conducted. In cases, Cox regression models were fit to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality. P values were adjusted using the Benjamini-Hochberg (BH) procedure for false dis

SUBMITTER: Petrick JL 

PROVIDER: S-EPMC8257775 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature