Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses.

ABSTRACT:

Background

Early life exposures impact immune system development and therefore the risk of immune-mediated diseases, including inflammatory bowel disease (IBD). We systematically reviewed the impact of pre-, peri‑, and postnatal exposures up to the age of five years on subsequent IBD diagnosis.

Methods

We identified case-control and cohort studies reporting on the association between early life environmental factors and Crohn's disease (CD), ulcerative colitis (UC), or IBD overall. Databases were search from their inception until May 24th, 2019 until July 14th, 2020. We conducted meta-analyses for quantitative review of relevant risk factors that were comparable across studies and qualitative synthesis of the literature for a wide range of early life exposures, including mat

SUBMITTER: Agrawal M 

PROVIDER: S-EPMC8257976 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature