The TDs/aptamer cTnI biosensors based on HCR and Au/Ti₃C₂-MXene amplification for screening serious patient in COVID-19 pandemic.

ABSTRACT: The accurate assay of cardiac troponin I (cTnI) is very important for acute myocardial infarction (AMI), it also can be employed as an effective index for screening serious patients in COVID-19 pandemic before fatal heart injury to reduce the mortality. A ratiometric sensing strategy was proposed based on electrochemiluminescent (ECL) signal of doxorubicin (Dox)-luminol or the electrochemical (EC) signal of methylene blue (MB) vs. referable EC signal of Dox. The bio-recognitive Tro4-aptamer ensures the high specificity of the sensor by affinity binding to catch cTnI, and the tetrahedral DNA (TDs) on Au/Ti₃C₂-MXene built an excellent sensing matrix. An in situ hybrid chain reaction (HCR) amplification greatly improved the sensitivity. The ratiometric sensing responses

SUBMITTER: Mi X 

PROVIDER: S-EPMC8258042 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature