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HLA-E-restricted, Gag-specific CD8+ T cells can suppress HIV-1 infection, offering vaccine opportunities.

ABSTRACT: Human leukocyte antigen-E (HLA-E) normally presents an HLA class Ia signal peptide to the NKG2A/C-CD94 regulatory receptors on natural killer (NK) cells and T cell subsets. Rhesus macaques immunized with a cytomegalovirus-vectored simian immunodeficiency virus (SIV) vaccine generated Mamu-E (HLA-E homolog)-restricted T cell responses that mediated post-challenge SIV replication arrest in >50% of animals. However, HIV-1-specific, HLA-E-restricted T cells have not been observed in HIV-1-infected individuals. Here, HLA-E-restricted, HIV-1-specific CD8 + T cells were primed in vitro. These T cell clones and allogeneic CD8 + T cells transduced with their T cell receptors suppressed HIV-1 replication in CD4 + T cells in vitro. Vaccine induction of efficacious HLA-E-restricted HIV-1-specific T cells should therefore be possible.

SUBMITTER: Yang H

PROVIDER: S-EPMC8258078 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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HLA-E-restricted, Gag-specific CD8<sup>+</sup> T cells can suppress HIV-1 infection, offering vaccine opportunities.

Yang Hongbing H Rei Margarida M Brackenridge Simon S Brenna Elena E Sun Hong H Abdulhaqq Shaheed S Liu Michael K P MKP Ma Weiwei W Kurupati Prathiba P Xu Xiaoning X Cerundolo Vincenzo V Jenkins Edward E Davis Simon J SJ Sacha Jonah B JB Früh Klaus K Picker Louis J LJ Borrow Persephone P Gillespie Geraldine M GM McMichael Andrew J AJ

Science immunology 20210301 57

Human leukocyte antigen-E (HLA-E) normally presents an HLA class Ia signal peptide to the NKG2A/C-CD94 regulatory receptors on natural killer (NK) cells and T cell subsets. Rhesus macaques immunized with a cytomegalovirus-vectored simian immunodeficiency virus (SIV) vaccine generated Mamu-E (HLA-E homolog)-restricted T cell responses that mediated post-challenge SIV replication arrest in >50% of animals. However, HIV-1-specific, HLA-E-restricted T cells have not been observed in HIV-1-infected i ...[more]

PMID: 33766848

Dataset Information

HLA-E-restricted, Gag-specific CD8+ T cells can suppress HIV-1 infection, offering vaccine opportunities.

Publications

HLA-E-restricted, Gag-specific CD8<sup>+</sup> T cells can suppress HIV-1 infection, offering vaccine opportunities.

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