The possible role of arsenic and gene-arsenic interactions in susceptibility to breast cancer: a systematic review.

ABSTRACT: The roles of many environmental contaminants in increasing breast cancer risk remain controversial. Arsenic (As) is a major global environmental contaminant and carcinogen. We conducted a systematic review of the role of As and gene-arsenic interactions in susceptibility to breast cancer. Following a systematic literature search using well-defined inclusion/exclusion criteria, a total of 15 epidemiologic studies (two meta-analyses, three systematic reviews, three cohort studies, two case-control studies, and five cross-sectional studies) were reviewed. In addition, several animal, in vitro, in vivo, and in silico (i.e., computer modeling) studies provided mechanistic insights into the association between As and breast cancer. Our review suggests a possible overall main

SUBMITTER: Moslehi R 

PROVIDER: S-EPMC8258236 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature