Latest Advances for the Treatment of Chronic Plaque Psoriasis with Biologics and Oral Small Molecules.

ABSTRACT: Psoriasis is a common immune-mediated chronic skin disease. Disease severity is influenced by several factors including the extent and localization of skin lesions, severity of pruritus and comorbidities, such as psoriatic arthritis. Moderate to severe psoriasis is defined when cutaneous involvement is diffuse, covering more than 10% of the body surface areas and/or involving the sensitive areas such as face, genitalia, folds or nails or has high impact on patients' quality of life, and it occurs in approximately 15% of cases. In recent years, a growing understanding of psoriasis pathophysiology allowed the development of an increasing number of effective and safe treatments, including biologicals that are indicated for moderate to severe psoriasis. Different classes of biologicals have be

SUBMITTER: Bellinato F 

PROVIDER: S-EPMC8258237 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature