Urinary Free Metanephrines for Diagnosis of Pheochromocytoma and Paraganglioma.

ABSTRACT:

Background

Pheochromocytoma and paraganglioma (PPGL) is diagnosed through biochemical confirmation of excessive catecholamines in urine and plasma. Recent technological developments have allowed us to measure urinary free metanephrines; however, the diagnostic accuracy of these new methods and the diagnostic cutoff values have not been evaluated.

Methods

This is a retrospective study of 595 subjects, including 71 PPGL cases and 524 controls. PPGL was based on pathological confirmation. Subjects with no evidence of PPGL over 2 years were included in the control group.

Results

Urinary free metanephrines yielded similar area under the curve (AUC) to urinary fractionated metanephrines and plasma free metanephrines. However, urinary free normetanephrine yielded a better AU

SUBMITTER: Ahn J 

PROVIDER: S-EPMC8258320 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature