Effect of Cigarette Smoking on Thyroid Cancer: Meta-Analysis.

ABSTRACT:

Background

Although smoking is generally carcinogenic, its effect on thyroid cancers is still subject to controversy. The purpose of this study was to summarize the role of smoking in relation to thyroid cancer occurrence.

Methods

We performed a meta-analysis of 24 eligible studies: 21 case-control studies and three prospective cohort studies. The summary odds ratio (OR) and 95% confidence interval (CI) of all studies were acquired based on random effect model. Further subgroup analyses were conducted according to gender, histological type of thyroid cancer, and smoking status of patients for the case-control studies.

Results

The summary effect size indicated a negative association of smoking for thyroid cancer (OR, 0.798; 95% CI, 0.681 to 0.935). From the subgroup an

SUBMITTER: Lee JH 

PROVIDER: S-EPMC8258339 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature