Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics.

ABSTRACT: Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement of multiple interconnected signaling pathways. Therefore, signaling receptors are major targets in pharmacological strategies in general. To provide a rationale for pharmacological interventions for sarcopenia, we herein describe several druggable signaling receptors based on their role in skeletal muscle homeostasis and changes in their activity with aging. A brief overview is presented of the efficacy of corresponding drug candidates under clinical trials. Strategies targeting the androgen receptor, vitamin D receptor, Insulin-like growth factor-1 receptor, and ghrelin receptor primar

SUBMITTER: Yoon JH 

PROVIDER: S-EPMC8258343 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature