Age patterns of HIV incidence in eastern and southern Africa: a modelling analysis of observational population-based cohort studies.

ABSTRACT:

Background

As the HIV epidemic in sub-Saharan Africa matures, evidence about the age distribution of new HIV infections and how this distribution has changed over the epidemic is needed to guide HIV prevention. We aimed to assess trends in age-specific HIV incidence in six population-based cohort studies in eastern and southern Africa, reporting changes in mean age at infection, age distribution of new infections, and birth cohort cumulative incidence.

Methods

We used a Bayesian model to reconstruct age-specific HIV incidence from repeated observations of individuals' HIV serostatus and survival collected among population HIV cohorts in rural Malawi, South Africa, Tanzania, Uganda, and Zimbabwe, in a collaborative analysis of the ALPHA network. We modelled HIV incidence rate

SUBMITTER: Risher KA 

PROVIDER: S-EPMC8258368 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature