Reductions in Gray Matter Linked to Epigenetic HIV-Associated Accelerated Aging.

ABSTRACT: A growing literature suggests a relationship between HIV-infection and a molecular profile of age acceleration. However, despite the widely known high prevalence of HIV-related brain atrophy and HIV-associated neurocognitive disorder (HAND), epigenetic age acceleration has not been linked to HIV-related changes in structural MRI. We applied morphological MRI methods to study the brain structure of 110 virally suppressed participants with HIV infection and 122 uninfected controls age 22-72. All participants were assessed for cognitive impairment, and blood samples were collected from a subset of 86 participants with HIV and 83 controls to estimate epigenetic age. We examined the group-level interactive effects of HIV and chronological age and then used individual estimations of epigenetic a

SUBMITTER: Lew BJ 

PROVIDER: S-EPMC8258439 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature