Hemodialysis Patients Have Impaired Cerebrovascular Reactivity to CO₂ Compared to Chronic Kidney Disease Patients and Healthy Controls: A Pilot Study.

ABSTRACT:

Introduction

Recurrent hemodialysis (HD)-induced ischemia has emerged as a mechanism responsible for cognitive impairment in HD patients. Impairment of cerebrovascular function in HD patients may render the brain vulnerable to HD-induced ischemic injury. Cerebrovascular reactivity to CO₂ (CVR) is a noninvasive marker of cerebrovascular function. Whether CVR is impaired in HD patients is unknown. In this study, we compared CVR between healthy participants, HD patients, and chronic kidney disease (CKD) patients not yet requiring dialysis.

Methods

This was a single-center prospective observational study carried out at Kidney Clinical Research Unit in London, Canada. We used carefully controlled hypercapnia to interrogate brain vasomotor control. Transcranial Doppler

SUBMITTER: Slessarev M 

PROVIDER: S-EPMC8258459 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature