Early-life famine exposure and rheumatoid arthritis in Chinese adult populations: a retrospective cohort study.

ABSTRACT:

Objective

This study aimed to explore the association between famine exposure in early life and the odds of rheumatoid arthritis (RA) in adulthood.

Design

A population-based retrospective cohort study.

Setting

China.

Participants

A total of 111 706 participants (1775 with RA) born from 1956 to 1964 were selected from the baseline survey of a large cohort in China.

Primary and secondary outcome measures

Four famine exposure groups were generated based on dates of birth, namely prenatal-exposed, infant-exposed, preschool-exposed and non-exposed groups. Logistic regressions were used to explore the association between famine exposure and self-reported RA in adulthood, adjusting for sex, region, monthly income, highest education, alcohol consumption, tobacco

SUBMITTER: Liu C 

PROVIDER: S-EPMC8258564 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature