Endothelial Endothelin Receptor A Expression Is Associated With Podocyte Injury and Oxidative Stress in Patients With Focal Segmental Glomerulosclerosis.

ABSTRACT:

Introduction

The podocyte is thought to be the mainly affected cell type in focal segmental glomerulosclerosis (FSGS). However, recent studies have also indicated a role for glomerular endothelial cells and podocyte-endothelial crosstalk in FSGS development. An experimental model for podocyte injury showed that increased endothelin-1 (ET-1) signaling between podocytes and endothelial cells induces endothelial oxidative stress and subsequent podocyte loss. In the current study, we investigated endothelial endothelin receptor A (ET_AR) expression in patients with FSGS and its association with podocyte injury and glomerular oxidative stress.

Methods

We selected 39 biopsy samples of patients with FSGS and 8 healthy control subjects, and stained them for ET_AR

SUBMITTER: van de Lest NA 

PROVIDER: S-EPMC8258598 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature