Association between cellular immune response and spleen weight in mice with hepatocellular carcinoma.

ABSTRACT: The spleen is an important site for extramedullary hematopoiesis and tumor immunotolerance. Spleen weight varies with tumor progression and may be a predictor of tumor recurrence. However, to the best of our knowledge, the association between spleen weight and tumor progression remains unclear. The present study revealed a novel role for the spleen in predicting the cellular immune response in tumor-bearing mice. A murine H22 subcutaneous hepatoma model was established. The spleen weight and tumor weight were measured. The proportion of immune cells in peripheral blood and spleen were detected by flow cytometry. The results demonstrated that the spleen weight of tumor-bearing mice at day 21 was higher than that of the controls. In addition, spleen weight was identified to be positively cor

SUBMITTER: Jiang W 

PROVIDER: S-EPMC8258616 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature