Schizosaccharomyces pombe Ppr10 and Mpa1 together mediate mitochondrial translational initiation.

ABSTRACT: Pentatricopeptide repeat (PPR) proteins are a large family of proteins that act primarily at different posttranscriptional steps of organellar gene expression. We have previously found that the Schizosaccharomyces pombe PPR protein mpal10 interacts with mitochondrial translational activator Mpa1, and both are essential for mitochondrial protein synthesis. However, it is unclear how these two proteins function in mitochondrial protein synthesis in S. pombe. In this study, we further investigated the role of Ppr10 and Mpa1 in mitochondrial protein synthesis. Mitochondrial translational initiation requires two initiation factors, Mti2 and Mti3, which bind to the small subunit of the mitochondrial ribosome (mt-SSU) during the formation of the mitochondrial translational initiation complex. Usi

SUBMITTER: Luo Y 

PROVIDER: S-EPMC8258696 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature