A hybrid stochastic/deterministic model of single photon response and light adaptation in mouse rods.

ABSTRACT: The phototransduction cascade is paradigmatic for signaling pathways initiated by G protein-coupled receptors and is characterized by a fine regulation of photoreceptor sensitivity and electrical response to a broad range of light stimuli. Here, we present a biochemically comprehensive model of phototransduction in mouse rods based on a hybrid stochastic and deterministic mathematical framework, and a quantitatively accurate description of the rod impedance in the dark. The latter, combined with novel patch clamp recordings from rod outer segments, enables the interconversion of dim flash responses between photovoltage and photocurrent and thus direct comparison with the simulations. The model reproduces the salient features of the experimental photoresponses at very dim and bright stimuli

SUBMITTER: Beelen CJ 

PROVIDER: S-EPMC8258797 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature