High-fat diet attenuates the improvement of hypoxia-induced pulmonary hypertension in mice during reoxygenation.

ABSTRACT:

Background

It is widely recognized that metabolic disorder is associated with pulmonary hypertension (PH). It is known that hypoxia-induced elevated pulmonary artery pressure in mice returns to normal pressure during reoxygenation. However, it is still unclear how metabolic disorder affects the reverse remodeling of pulmonary arteries. In this study, we investigated the effects of high-fat diet (HFD) on the decrease in pulmonary artery pressure and reverse remodeling of pulmonary arteries in mice with hypoxia-induced PH.

Methods

We used female C57BL/6 mice aged 8 weeks. After being exposed to hypoxia (10% oxygen for four weeks) to induce PH, the mice were returned to normoxic conditions and randomized into a normal diet (ND) group and HFD group. Both groups were fed with the

SUBMITTER: Sugimoto K 

PROVIDER: S-EPMC8258936 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature