Associations of reproductive breast cancer risk factors with breast tissue composition.

ABSTRACT:

Background

We investigated the associations of reproductive factors with the percentage of epithelium, stroma, and fat tissue in benign breast biopsy samples.

Methods

This study included 983 cancer-free women with biopsy-confirmed benign breast disease (BBD) within the Nurses' Health Study and Nurses' Health Study II cohorts. The percentage of each tissue type (epithelium, stroma, and fat) was measured on whole-section images with a deep-learning technique. All tissue measures were log-transformed in all the analyses to improve normality. The data on reproductive variables and other breast cancer risk factors were obtained from biennial questionnaires. Generalized linear regression was used to examine the associations of reproductive factors with the percentage of tissue typ

SUBMITTER: Yaghjyan L 

PROVIDER: S-EPMC8258947 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature