A computational multi-targeting approach for drug repositioning for psoriasis treatment.

ABSTRACT:

Background

Psoriasis is an autoimmune inflammatory skin disease that affects 0.5-3% of the world's population and current treatment options are posed with limitations. The reduced risk of failure in clinical trials for repositioned drug candidates and the time and cost-effectiveness has popularized drug reposition and computational methods in the drug research community.

Results

The current study attempts to reposition approved drugs for the treatment of psoriasis by docking about 2000 approved drug molecules against fifteen selected and validated anti-psoriatic targets. The docking results showed that a good number of the dataset interacted favorably with the targets as most of them had - 11.00 to - 10.00 kcal/mol binding free energies across the targets. The percentage of

SUBMITTER: Ibezim A 

PROVIDER: S-EPMC8258956 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature