Postoperative delirium mediates 180-day mortality in orthopaedic trauma patients.

ABSTRACT:

Background

Frailty has been associated with increased incidence of postoperative delirium and mortality. We hypothesised that postoperative delirium mediates a clinically significant (≥1%) percentage of the effect of frailty on mortality in older orthopaedic trauma patients.

Methods

This was a single-centre, retrospective observational study including 558 adults 65 yr and older, who presented with an extremity fracture requiring hospitalisation without initial ICU admission. We used causal statistical inference methods to estimate the relationships between frailty, postoperative delirium, and mortality.

Results

In the cohort, 180-day mortality rate was 6.5% (36/558). Frail and prefrail patients comprised 23% and 39%, respectively, of the study cohort. Frailty was asso

SUBMITTER: Pedemonte JC 

PROVIDER: S-EPMC8258970 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature